abstract：:Amyloids are the fibrillar protein aggregates with cross-β structure. Traditionally amyloids were associated with pathology, however, nowadays more data is emerging about functional amyloids playing essential roles in cellular processes. We conducted screening for functional amyloids in rat brain. One of the identifie...

authors： Chirinskaite AV,Siniukova VA,Velizhanina ME,Sopova JV,Belashova TA,Zadorsky SP

更新日期：2021-12-01 00:00:00

abstract：:Eye drops are considered standard practice for the delivery of ocular drugs. However, low patient compliance and low drug levels compromise its effectiveness. Our group developed a ketorolac-loaded ocular coil for sustained drug delivery up to 28 days. The aim of this study was to gain insight into the pharmacokinetic...

authors： Bertens CJF,Gijs M,Dias AAJ,van den Biggelaar FJHM,Ghosh A,Sethu S,Nuijts RMMA

更新日期：2021-12-01 00:00:00

abstract：OBJECTIVES:Previous study (Br. J. Haematol. 2017; 176:498) reported that CD56 positive is associated with poor prognosis of patients with intermediate-risk acute myeloid leukemia (IR-AML). However, our data were inconsistent with the finding. Thus, in this study, we provided the different results to discuss. METHODS:A...

authors： Chen C,Chio CL,Zeng H,Li Y

更新日期：2021-12-01 00:00:00

abstract：CONTEXT:Rosmarinic acid (RosA), a natural poly-phenolic compound isolated from a variety of Labiatae herbs, has been reported to have a range of biological effects. OBJECTIVE:To investigate the cardioprotective effects of RosA against myocardial ischaemia/reperfusion (I/R) injury. MATERIALS AND METHODS:Male C57BL/6J ...

authors： Quan W,Liu HX,Zhang W,Lou WJ,Gong YZ,Yuan C,Shao Q,Wang N,Guo C,Liu F

更新日期：2021-12-01 00:00:00

abstract：:The Medical Student Performance Evaluation (MSPE) is an important tool of communication used by program directors to make decisions in the residency application process. To understand the perspective and usage of the MSPE across multiple medical specialties now and in anticipation of the planned changes in USMLE Step ...

authors： Bird JB,Friedman KA,Arayssi T,Olvet DM,Conigliaro RL,Brenner JM

更新日期：2021-12-01 00:00:00

abstract：:The objective of this research was to evaluate consequences to the immune system of long-term exposure to waste anesthetic gases (WAG) by medical theater personnel. Two groups were recruited: (i) 60 healthy male controls; (ii) 120 medical professionals exposed to WAG, subdivided according to theater role, i.e. surgeon...

authors： Emara AM,Alrasheedi KA,Alrashidi SD,Elgharabawy RM

更新日期：2021-12-01 00:00:00

abstract：:An Antarctic wintering-over station is a unique environment, as a small isolated society facing extreme survival margins. Psychological surveys have been done over ten years, including the Baum test, the Positive and Negative Affect Schedule (PANAS), the Coping Orientation to Problems Experienced (COPE), Subjective He...

authors： Kuwabara T,Naruiwa N,Kawabe T,Kato N,Sasaki A,Ikeda A,Otani S,Imura S,Watanabe K,Ohno G

更新日期：2021-12-01 00:00:00

abstract：:Poor cellular uptake and slow intracellular drug release remain the main barriers for the efficient application of micellar delivery system. Taking advantage of the overexpressed CD44 receptor and mild acidic microenvironment of tumour cells, CD44-targeted pH-responsive micelles based on the self-assembly of histidine...

authors： Yang S,Chen W,Li W,Song J,Gao Y,Si W,Li X,Cui B,Yu T

更新日期：2021-12-01 00:00:00

abstract：BACKGROUND:Charcot neuroarthropathy of the ankle is an extremely challenging clinical dilemma, and its surgical management can be highly complicated. The goal of Charcot ankle treatment is to to restore a plantigrade and stable foot, and thus to avoid ulceration with subsequent infection. This report aims to introduce ...

authors： Wang G,Lin J,Zhang H,Pei Y,Zhu L,Xu Q

更新日期：2021-12-01 00:00:00

abstract：:Human intestinal epithelial cell line-6 (HIEC-6) cells and primary human hepatocytes (PHHs) were treated with 3-amidinophenylalanine-derived inhibitors of trypsin-like serine proteases for 24 hours. It was proven that treatment with MI-1900 and MI-1907 was tolerated up to 50 μM in HIEC-6. These inhibitors did not caus...

authors： Pászti-Gere E,Pomothy J,Jerzsele Á,Pilgram O,Steinmetzer T

更新日期：2021-12-01 00:00:00

abstract：:Indigenous Arctic Canadians have a higher prevalence of gastric neoplasms relative to North Americans of European ancestry. We investigated the hypothesis that low-dose methylmercury exposure from eating fish/whale increases the risk of gastric cancer in Arctic communities. We used intermediate endpoints from an estab...

authors： Walker EV,Girgis S,Yuan Y,Goodman KJ

更新日期：2021-12-01 00:00:00

abstract：OBJECTION:Immunotherapy based on T cells is a new therapy for Acute myeloid leukemia (AML). However, there has not been considerable improvement compared with traditional chemotherapeutics. This study aimed to identify important immune cells, genes, and drugs associated with the immunotherapy of AML. METHODS:The gene ...

authors： Jia M,Zhang H,Wang L,Zhao L,Fan S,Xi Y

更新日期：2021-12-01 00:00:00

abstract：:Bacterial proteases and peptidases are integral to cell physiology and stability, and their necessity in Streptococcus pneumoniae is no exception. Protein cleavage and processing mechanisms within the bacterial cell serve to ensure that the cell lives and functions in its commensal habitat and can respond to new envir...

authors： Marquart ME

更新日期：2021-12-01 00:00:00

abstract：:In discovery of novel HDAC inhibitory with anticancer potency, pharmacophores of phenanthridine were introduced to the structure of HDAC inhibitors. Fatty and aromatic linkers were evaluated for their solubility and activity. Both enzyme inhibitory and in vitro antiproliferative (against U937 cells) screening results ...

authors： Fan W,Zhang L,Wang X,Jia H,Zhang L

更新日期：2021-12-01 00:00:00

abstract：:Human Cytochrome P450 2J2 (CYP2J2) as an important metabolic enzyme, plays a crucial role in metabolism of polyunsaturated fatty acids (PUFAs). Elevated levels of CYP2J2 have been associated with various types of cancer, and therefore it serves as a potential drug target. Herein, using a high-throughput screening appr...

authors： Tian X,Zhou M,Ning J,Deng X,Feng L,Huang H,Yao D,Ma X

更新日期：2021-12-01 00:00:00

abstract：:Purpose: To explore how people with end stage chronic obstructive pulmonary disease and their family members describe living in the face of impending death.Methods: A narrative inquiry was undertaken using a social constructionist perspective. Data were collected in 2017-18 in two in-depth interviews, lasting 90 to 12...

authors： Molzahn AE,Sheilds L,Antonio M,Bruce A,Schick-Makaroff K,Wiebe R

更新日期：2021-12-01 00:00:00

abstract：:The novel coronavirus disease COVID-19, caused by the virus SARS CoV-2, has exerted a significant unprecedented economic and medical crisis, in addition to its impact on the daily life and health care systems all over the world. Regrettably, no vaccines or drugs are currently available for this new critical emerging h...

authors： El Hassab MA,Ibrahim TM,Al-Rashood ST,Alharbi A,Eskandrani RO,Eldehna WM

更新日期：2021-12-01 00:00:00

abstract：:Background: The relationship between hematuria, a typical presentation of immunoglobulin A nephropathy (IgAN), and long-term adverse prognosis of these patients is still controversial. This meta-analysis aims to clarify the effect of hematuria on renal outcomes in IgAN.Methods: Observational cohort studies reporting a...

authors： He P,Wang H,Huang C,He L

更新日期：2021-12-01 00:00:00

abstract：:A rapid, one-pot synthesis of eight benzo[a]furo[2,3-c]phenazine derivatives has been achieved in moderate to good yields in good yields via a multi-component of 2-hydroxynaphthalene-1,4-dione, arylglyoxal, indole (H, CH3) in the presence of H3PW12O40@Fe3O4-ZnO magnetic core-shell nanoparticles (MCNPs) under solvent-f...

authors： Taheri M,Mohebat R,Moslemin MH

更新日期：2021-12-01 00:00:00

abstract：:Studies have shown that sexual transmission, both heterosexually and homosexually, is one of the main ways of HBV infection. Based on this fact, we propose a mathematical model to study the sexual transmission of HBV among adults by classifying adults into men and women and considering both same-sex and opposite-sex t...

authors： Lu M,Shu Y,Huang J,Ruan S,Zhang X,Zou L

更新日期：2021-12-01 00:00:00

abstract：BACKGROUND:Macroscopic hematuria after wasp sting has been reported in Asia to occur before acute kidney injury (AKI), and is often used by clinicians as a sign indicating the need for intensive care and blood purification therapy. However, there is no study on the clinical characteristics and prognosis of this symptom...

authors： Wang M,Prince S,Tang Y,Zhong X,Chen S,Li G,Wang L,Wang W

更新日期：2021-12-01 00:00:00

abstract：:The variegated squirrel bornavirus 1 (VSBV-1) is a recently discovered emerging viral pathogen which causes severe and eventually fatal encephalitis in humans after contact to exotic squirrels in private holdings and zoological gardens. Understanding the VSBV-1 epidemiology is crucial to develop, implement, and mainta...

authors： Cadar D,Allendorf V,Schulze V,Ulrich RG,Schlottau K,Ebinger A,Hoffmann B,Hoffmann D,Rubbenstroth D,Ismer G,Kibbey C,Marthaler A,Rissland J,Leypoldt F,Stangel M,Schmidt-Chanasit J,Conraths FJ,Beer M,Homeier-Bachmann T

更新日期：2021-12-01 00:00:00

abstract：:ABSTRACTThe recent impact of Ebola virus disease (EVD) on public health in Africa clearly demonstrates the need for a safe and efficacious vaccine to control outbreaks and mitigate its threat to global health. ERVEBO® is an effective recombinant Vesicular Stomatitis Virus (VSV)-vectored Ebola virus vaccine (VSV-EBOV) ...

authors： Morozov I,Monath TP,Meekins DA,Trujillo JD,Sunwoo SY,Urbaniak K,Kim IJ,Narayanan SK,Indran SV,Ma W,Wilson WC,O'Connor C,Dubey S,Troth SP,Coller BA,Nichols R,Martin BK,Feldmann H,Richt JA

更新日期：2021-12-01 00:00:00

abstract：:In 2006, abortion in Colombia was decriminalised under certain circumstances. Yet some women continue to avail themselves of ways to terminate pregnancies outside of the formal health system. In-depth interviews (IDIs) with women who acquired drugs outside of health facilities to terminate their pregnancies (n = 47) w...

authors： Moore AM,Ortiz J,Blades N,Whitehead H,Villarreal C

更新日期：2021-12-01 00:00:00

abstract：BACKGROUND:The conflicting results of studies on intensive care unit (ICU) mortality of obese patients and obese patients with acute kidney injury (AKI) reveal a paradox within a paradox. The aim of this study was to determine the effects of body mass index and obesity on AKI development and ICU mortality. METHODS:The...

authors： Sabaz MS,Aşar S,Sertçakacılar G,Sabaz N,Çukurova Z,Hergünsel GO

更新日期：2021-12-01 00:00:00

abstract：:To increase the amount of pirfenidone (PFD) loaded in polyvinyl alcohol (PVA) film embedded soft contact lens (SCL), and evaluate its function of sustaining delivery of drug in vitro and in vivo. Drug loading efficiency within PVA film and SCLs, drug release from SCLs in vitro, and the effects of parameters of SCLs an...

authors： Wu C,Or PW,Chong JIT,K Pathirage Don IK,Lee CHC,Wu K,Yu M,Lam DCC,Yang Y

更新日期：2021-12-01 00:00:00

abstract：:Clear cell renal cell carcinoma (ccRCC) is the most common type with poor prognosis in kidney tumor. Growing evidence has indicated that aberrant alternative splicing (AS) events are efficacious signatures for tumor prognosis prediction and therapeutic targets. However, the detailed roles of AS events in ccRCC are lar...

authors： Zhang D,Zhang W,Sun R,Huang Z

更新日期：2021-12-01 00:00:00

abstract：:In this study, we construct a subcutaneous tumor mice model of U14 cells, observe the tumor growth, and detect the expression of Foxp3 and VISTA in cervical cancer tissues and adjacent tissues during CMNa-enhancing radiotherapy.From the 15th day, compared with the control group, the tumor volume changes in each treatm...

authors： Li L,Shi W,Zhou J

更新日期：2021-12-01 00:00:00

abstract：PURPOSE:Eplerenone (EPL) is a selective mineralocorticoid receptor antagonist used for treatment of chronic central serous chorioretinopathy which characterized by accumulation of subretinal fluid causing a localized area of retinal detachment. unfortunately, EPL suffers from poor oral bioavailability due to poor aqueo...

authors： Abd-Elhakeem E,El-Nabarawi M,Shamma R

更新日期：2021-12-01 00:00:00

abstract：CONTEXT:ECa 233 is the standardized extract of Centella asiatica (L.) Urban. (Apiaceae). It contains at least 85% of triterpenoid glycosides and yields neuroprotective and memory-enhancing effects. However, the exact molecules exerting the effects might be triterpenic acid metabolites reproduced through gut metabolism ...

authors： Boondam Y,Tantisira MH,Tilokskulchai K,Tapechum S,Pakaprot N

更新日期：2021-12-01 00:00:00

abstract：:Viruses are intracellular pathogens and are dependent on host cellular resources to carry out their cycles of perpetuation. Obtaining an integrative view of host-virus interaction is of utmost importance to understand the complex and dynamic interplay between viral components and host machineries. Besides its obvious ...

authors： Patra U,Mukhopadhyay U,Mukherjee A,Dutta S,Chawla-Sarkar M

更新日期：2021-12-01 00:00:00

abstract：:Bullous pemphigoid (BP) is an autoimmune subepidermal blistering disease. Although several cases of BP in end-stage renal disease patients receiving peritoneal dialysis (PD) or hemodialysis have been reported, the incidence of BP in these patients remains unknown. We recently experienced three PD patients diagnosed wi...

authors： Morimoto K,Yoshida T,Washida N,Uchiyama K,Nakayama T,Itoh H,Oya M

更新日期：2021-12-01 00:00:00

abstract：:MAGI1 is an intracellular adaptor protein that stabilizes cell junctions and regulates epithelial and endothelial integrity. Here, we report that that in endothelial cells MAGI1 colocalizes with paxillin, β3-integrin, talin 1, tensin 3 and α-4-actinin at mature focal adhesions and actin stress fibers, and regulates th...

authors： Alday-Parejo B,Ghimire K,Coquoz O,Albisetti GW,Tamò L,Zaric J,Stalin J,Rüegg C

更新日期：2021-12-01 00:00:00

abstract：BACKGROUND:The Oxford classification of IgA nephropathy (IgAN) was revised in 2016 which lacked sufficient evidence for prognostic value of subclassification of focal segmental glomerular sclerosis (S lesion), and the proper proportion of S lesion for subclassification remains undetermined. AIM:This study aimed to exp...

authors： Yu F,Zhu X,Yuan S,Chen X,Li Z,Qu Z,Liu H,Sun L,Liu F

更新日期：2021-12-01 00:00:00

abstract：:Vitamin D is known to elicit many biological effects in diverse tissue types and is thought to act almost exclusively upon its canonical receptor within the nucleus, leading to gene transcriptional changes and the subsequent cellular response. However, not all the observed effects of vitamin D can be attributed to thi...

authors： Long W,Johnson J,Kalyaanamoorthy S,Light P

更新日期：2021-12-01 00:00:00

abstract：:High viability and further adipogenic differentiation of adipose-derived stem cells (ADSCs) are fundamental for engraftment and growth of the transplanted adipose tissue. It has been demonstrated that extracellular matrix (ECM) regulates cell proliferation and differentiation by interacting with ERK1/2 signalling path...

authors： Qian Y,Chen H,Pan T,Li T,Zhang Z,Lv X,Wang J,Ji Z,He Y,Li L,Lin M

更新日期：2021-12-01 00:00:00

abstract：:RNA-binding motif protein 25 (RBM25) is a poorly characterized RNA-binding protein that is involved in several biological processes and regulates the proliferation and metastasis of tumor cells. The regulatory role of RBM25 in hepatocellular carcinoma (HCC) is unknown. Here, RBM25 expression and outcomes in HCC patien...

authors： Zhang YF,Wang YX,Zhang N,Lin ZH,Wang LR,Feng Y,Pan Q,Wang L

更新日期：2021-12-01 00:00:00

abstract：:Pathogenic Candida albicans yeasts frequently cause infections in hospitals. Antifungal drugs lose effectiveness due to other Candida species and resistance. New medications are thus required. Secreted aspartic protease of C. parapsilosis (Sapp1p) is a promising target. We have thus solved the crystal structures of Sa...

authors： Dostál J,Brynda J,Vaňková L,Zia SR,Pichová I,Heidingsfeld O,Lepšík M

更新日期：2021-12-01 00:00:00

abstract：:West Nile virus (WNV) is a flavivirus which transmission cycle is maintained between mosquitoes and birds, although it occasionally causes sporadic outbreaks in horses and humans that can result in serious diseases and even death. Since its first isolation in Africa in 1937, WNV had been considered a neglected pathoge...

authors： Saiz JC,Martín-Acebes MA,Blázquez AB,Escribano-Romero E,Poderoso T,Jiménez de Oya N

更新日期：2021-12-01 00:00:00

abstract：:Ataxia telangiectasia (A-T) is a rare childhood autosomal recessive neurodegenerative chromosomalin stability disorder. It is characterized by high risk of hematological malignancies with T-cell phenotype being the most common, which can present first before the diagnosis of A-T made. The chromosomalin stability in A-...

authors： Ahmed O,Felimban Y,Almehdar A

更新日期：2021-12-01 00:00:00